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New Depression Medications in the Works

  • Writer: Shannon Coulson
    Shannon Coulson
  • Oct 8, 2025
  • 1 min read

🧪 Drugs / Treatments in Development / Emerging

  • Hydroxynorketamine (HNK)

    • Being studied as a metabolite of ketamine with the hope that it may have rapid antidepressant effects without some of the dissociative side effects of ketamine. National Institute of Mental Health+1

  • NRX-101 / NRX-100 (by NRx Pharmaceuticals)

    • These are being developed for severe cases, including suicidal depression and bipolar depression. One is an IV ketamine formulation (NRX-100), the other is a combination (D-cycloserine + lurasidone) aimed at bipolar depression and suicidal ideation

 
 
 

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